Low density Polyethylene (PE) based polymeric medical devices such as medical tubing have been observed to fail in real life situations as a result of environmental stress cracking (ESC) occurring due to the combined effect of a low level of mechanical stress combined with chemical exposure. ESC can result in catastrophic failures of products including medical devices during their service life without any visible warnings. To investigate this, the ESC behaviour of PE based samples used in medical tubing was investigated experimentally using both the ASTM D1693 and ISO 22088-3 test standards. Injection moulded PE samples were produced with varying amounts (2-8%) of Ethylene Vinyl Acetate (EVA) and with two types of additives (a pigment and an antimicrobial agent) before being exposed to two solvents commonly used as assembly aids (MEK and IPA). EVA an elastomeric polymer, was blended with PE in an attempt to increase ESC resistance, by improving the toughness. It was found that the addition of the additives made the material more susceptible to ESC and that the addition of EVA afforded a degree of protection against stress cracking. It is believed that findings from this work will be helpful across a range of industries by helping to reduce the risk of unexpected ESC failure of safety critical PE components.