In this study, Nylon 6 (PA) (Bergamid B65 Natur-TP, supplied from PolyOne) matrix was reinforced with purified, fine grinded and amino-silane treated halloysite nanotubes (ESH HNT S, developed by Esan R&D) at different concentrations. The preparation of composites was carried out using lab-scale twin screw micro-extruder (15 ml microcompounder®, DSM Xplore) with the loading ratios of 0.5, 1, 3 and 20 wt %. The test samples were shaped by injection-molding process. Surface characteristics of HNT samples were confirmed by infrared spectroscopy in ATR mode. Mechanical, thermal, structural and processing investigations of PA-based nano-composites were reported performing tensile, hardness, impact tests, differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), transmission electron microscopy (TEM), X-ray diffraction analysis and equipment force measurements, respectively. According to mechanical test results, additions of nanotubes to PA matrix caused improvements for tensile strength and Youngs’ modulus parameters. The addition of amino-silane modified halloysite resulted with better impact resistance even at very high loading level. According to ATR results, siloxane formations stem from the bonding of silane agent to hydroxyl groups of HNT surface. Thermal studies revealed that decomposition temperature (Td) of PA shifted to higher values after HNT inclusions regardless of concentration. Morphology and HNT distributions were examined by the help of both XRD and TEM studies in which halloysite nano tubes exhibited good dispersion and distribution in PA 6 matrix.