As the molding simulation technology evolved, it has now been widely used in the early stage of product development to help navigate and make important design decisions, avoiding costly mistakes that might occur during production. However, in the traditional injection molding simulation procedure, the screw movement is simply transferred into the flow rate and pressure imposed on the sprue without considering any machine response. This not only resulted in an ineffective communication for the simulation inputs between CAE engineers and machine operators, but also further brings an unexpected gap between simulation results and manufacturing process. In this research, we’ll demonstrate how to consider the dynamic characteristics of an injection molding machine in simulations through the machine characterization process, which allows engineers to input the real-world machine parameters, such as filling speed and pressure response. In addition, the dynamic screw movement inside the barrel is considered to simulate the actual compression behavior of melts from screw to tip to the nozzle. By integrating the three dimensional simulation model of real-world machine parameters and the actual barrel compression behavior, we can get a more realistic description of the dynamic behavior of melts entering the cavity and further generate a more accurate injection pressure prediction.