The crystallization of semi-crystalline thermoplastics under injection molding conditions is highly dependent on the thermo-mechanical history experienced by the polymer material during the shaping process. In the last decades, great efforts have been made to model polymer crystallization under such conditions while considering the flow history of the melt. A common modelling approach for describing flow-induced crystallization is based on the Avrami-Kolmogorov nucleation and growth theory combined with Schneider’s rate equations. Such method necessitates however the experimental determination of a high number of model parameters and solving an intricate system of differential equations. In this work, we propose the use of a simpler thermo-mechanical crystallization model developed by Poitou et al. [1] in the framework of irreversible thermodynamics to describe the flow-induced crystallization of an unreinforced semi-crystalline thermoplastic material during injection molding. The model is implemented in 3D in the commercial software Autodesk® Moldflow® Insight 2021 using the Solver API feature. We present a numerical sensitivity analysis of the model implementation as well as a framework for data-driven calibration to a particular semi-crystalline thermoplastic material.