In this study, two proportions of thermo-and-pH-sensitive copolymer poly(N-vinylcaprolactam-co-acrylic acid) (Poly(NVCL-co-AA)) were synthesized by free radical polymerization: 80 mol % of NVCL; 20 mol % of AA and 70 mol % of NVCL; 30 mol % of AA. Nanofiber scaffolds to be used in Drug Delivery applications were obtained by electrospinning Poly(NVCL-co-AA) and several of its blends with Ketoprofen, a hydrophobic drug. The process parameters to obtain smooth and beadless poly(N-vinylcaprolactam-co-Acrylic acid)/ ketoprofen nanofibers were optimized. All obtained fibers mats were characterized by scanning electron microscopy. Their lower critical solution temperature (LCST) was evaluated by UV-visible Spectrophotometer. The crystallinity of the drugs inside the fibers was evaluated by differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analysis. The interaction between the drug and carrier polymer was investigated using Fourier transform infrared spectrometer (FTIR) spectra. The drug entrapment efficiency and release of the obtained fibers meshes were evaluated using UV-visible Spectrophotometer. The FTIR analyses indicated that drug was trapped in the Fibers. It was shown that the drug delivery depends on fibers morphology and both temperature and pH of the release environmental parameters.