Keywords: Thermosensitive, Gel, Thermal properties, Rheological properties, SAXS, SANS, Drug Release, Pluronic, Colloidal Crystals, Delivery Systems. Understanding structure-property relationships is critical for the development of new drug delivery systems. This study investigates the properties of Pluronic smart hydrogel formulations for future use as injectable controlled drug carriers. The smart hydrogels promise to enhance patient compliance, decrease side effects and reduce dose and frequency. Pharmaceutically, these polymeric systems are attractive due to their unique sol-gel phase transition in the body, biocompatibility, safety and injectability as solutions before transforming into gel matrices at body temperature. The structural changes of F127 systems are quantified under controlled temperature after flow, as experienced during real bodily injection. Empirical formulae combining the coupled thermal and shear dependency are produced to aid future application of these systems. Induced structural transitions measured in-situ by small angle x-ray and neutron scattering reveal mixed oriented structures that can be exploited to tailor the syringeability/ injectability during clinical use as well as the loaded drug deposition within the crystalline matrix, which will ultimately affect the drug release profile.