Ultra-high molecular weight polyethylene (UHMWPE) has been regarded as a representative of bio-materials, especially for artificial prostheses for long term knee/hip joint use. However, the wear resistance still need to be improved under long term using. Graphene is regarded as the dream reinforce material among all of the carbon base filler due to its excellent lubricate property. In this work, we have produced nanocomposites using a novel octa-screw kneading machine with graphene as the fillers to increase the mechanical anti-wear property. The dispersion of graphene in the composites matrix and the influence of processing conditions was investigated. The experimental results suggested that the melt mass flow rate increased from 0.78 to 1.1 after 1.0 wt% of graphene was added. The crystallinities of these composites increased from 65.95 to 67. The wear resistance of these composites was improved by 20% after 1% graphene of 8 nm in size was added. In this presentation, we will discuss the friction and wear properties of graphene filled composites with different contents.