An oral drug delivery composite based on hybrid gelatin microparticles (MP) and montmorillonite clay (MMT) was characterized by SEM and TEM, thermal properties with DSC and in vitro biocompatibility by cell viability in a MTT assay with Fibroblast NIH3T33T3 cells. The mucoadhesive properties were studied with the rheological synergism determination trough viscoelastic oscillatory tests by viscoelastic properties of the interaction between isolated mucin and the MP/MMT final composite and the individual components (MP and MMT), were the pH and frequency effect were evaluated. The results showed that the MP/MMT composite has an improvement in thermal stability, and good biocompatibility with high cell proliferation. To our knowledge there is not previous reports about determination of rheological synergism of MMT. Besides, in the mucoadhesion study the rheological synergism showed dependence with pH and frequency. Also, the interaction between mucin and MP, MMT or MP/MMT had different behaviors due the degree and type of interaction. The MP/MMT showed the highest rheological synergism related to the biggest interaction with mucin at pH 1.6.