Medical devices that are in contact with the human body circulation have to be sterile to fulfill the safety requirements of national or international regulations. Therefore, gamma and electron beam sterilization are common established technologies as well as X-ray sterilization, which has become more interesting over the past years. Unfortunately some widely used polymers in the medical field like polypropylene are susceptible to high energy radiation leading to optical (yellowing) and mechanical (embrittlement) changes due to degradation mechanisms. Using stabilizing additives is the common way to overcome these problems leading to some special so-called radiation stable polypropylene grades on the market. This study compares the impact of three different radiation sterilization methods at a dose of 45 kGy on a commercially available radiation stable polypropylene from the market. Macroscopic properties like mechanical behaviour and yellowing accompanied by structural investigations like molecular mass (Size Exclusion Chromatography) have been investigated. As time after sterilization is also an important factor for degradation mechanisms all investigations were compared initially after sterilization as well as after sterilization and subsequent accelerated aging cycles.