Biomaterials are widely used as a drug delivery system. In recent years local drug delivery has been extensively studied to improve the pharmacokinetics of drugs. Thermoresponsive polymers are mostly used as a drug delivery system. Poly N-vinylcaprolactam (PNVCL) is a thermoresponsive polymer that exhibit LCST behavior in aqueous solution around 32 ᵒC. Thermoresponsive polymers switch its behavior at the higher temperature of LCST. The hydrophilic polymer change to hydrophobic behavior due to disappeared the interaction between carbonyl groups of PNVCL and hydroxyl groups of Aquos environments. Control LCST near the human body is the most important parameter for successful protein delivery system. To increase phase transition temperature, carboxymethylcellulose is a hydrophilic biocompatible polymer that makes it appropriate for copolymerization with PNVCL. In this work, we prepared thermoresponsive PNVCL/ carboxymethylcellulose semi IPN nanogels(MTRSI-NGs). At first, PNVCL were synthesized via free radical polymerization, and then carboxymethylcellulose was crosslinked in Fe3O4 presence. FTIR spectra confirmed the formation of MTRSI-NGs. The phase transition temperature was determined by Rheological and turbidimetry analysis. The turbidimetry analysis was shown LCST of PNVCL and magnet-free nanogels around 32 and 37 ᵒC respectively. Rheological analysis showed phase transition temperature around 38 ᵒC that confirm turbidimetry results. On the other hand, the rheological analysis was confirmed semi IPN nanogels by the thermoresponsive behavior of magnetic nanogels.