Significant progress has been achieved in the past years in the preparation of mechanically strong supramolecular polymers and hydrogels with several smart functions (1). Inspired by natural healing processes, reversible molecular interactions including H-bonding and hydrophobic interactions have been used recently to generate self-healing materials. In this talk I will present recent developments in this field by highlighting our ongoing research on self-healing and shape-memory materials (2-7). Several synthetic strategies for the preparation of supramolecular hydrogels, and rubbers exhibiting self-healing and shape-memory functions will be discussed and their potential application areas will be presented. References 1) C. Creton, Macromolecules 50, 8297-8316 (2017) 2) D. C. Tuncaboylu, M. Sahin, A. Argun, W. Oppermann, O. Okay, Macromolecules 45, 1991-2000 (2012) 3) C. Bilici, O. Okay, Macromolecules 46, 3125-3131 (2013) 4) V. Can, Z. Kochovski, V. Reiter, N. Severin, M. Siebenbürger, B. Kent, J. Just, J. P. Rabe, M. Ballauff, O. Okay, Macromolecules 49, 2281-2287 (2016) 5) C. Bilici, V. Can, U. Nöchel, M. Behl, A. Lendlein, O. Okay. Macromolecules 49, 7442-7449 (2016) 6) A. Argun, U. Gulyuz, O. Okay, Macromolecules 51, 2437-2446 (2018) 7) A. T. Uzumcu, O. Guney, O. Okay, ACS Appl. Mater. Interfaces 10, 8296-8306 (2018)