Reactive Compounding with the use of high energy electrons to form polymer radicals was recently developed as a novel process for modification and mixing of polymers. This process opened the way to create unique polymer materials in the fields of compounds, blends and modified polymers. The use of high energy electrons improves significantly the controllability of the process but on the other hand unusual parameters for polymer engineers should be tuned. The interaction between process parameters of classical compounding and of the controlled treatment with high energy electrons will be described and using different examples demonstrated. The Electron induced reactive compounding requires special mixing equipment as well as adapted electron accelerators. The construction ideas as well as the special boundary conditions for processing will be illustrated. Finally the challenges for scale up of the process including the safety requirements will be discussed and first solutions will be shown. The advantages and disadvantages of the realized solutions will be described. The challenges for the next scale up step will be discussed.