Our research group focuses on the synthesis and characterizations of different types of stimuli-responsive (co)polymers which have great response to external conditions. They can self-assemble and form various nanostructures (micelles, gels, flocculates...) depending on a change of pH, temperature, ionic strength of the medium. They are getting more and more attention for various applications such as in biomedical technology (as antibacterial agents, drug carriers, controlled releasing systems etc), in sensor technology, in cosmetics. Recently, we have focused on poly(glycidyl methacrylate) based block copolymers and their derivatizations with morpholine, piperazine and tertiary amine type reactants which provide a way to tune surface activity, water solubility and self-assembly. Additionally, derivative polymers can also be converted into different structures with further reactions. They can self-assemble and form core-shell micellar structures depending on solution conditions due to having a stimuli-responsive block. Important outcomes of these copolymers are their usage as (i) stabilizers in heterogeneous polymerizations, multi-responsive microgels, nanometal dispersions, (ii) source for novel cross-linked micelles, hydrogels, antibacterial materials, LbL nanofilms, etc. On the other hand, we also succeeded to prepare a novel multi-responsive microgel of water soluble monomer and “microgel-liposome” system having a potential in drug targeting/releasing applications. Keywords: Self-assembly, cross-linking, micelles, microgels, hydrogels, stimuli-responsive.