Nanocomposites attracted significant research interest in the last decades. Applications have been developed in the automotive, packaging, and many other industries because of significant improvements in performances and cost. The structure and performances of polymer nanocomposites films, in particular, are the result of the microstructure that is imparted to the material as a result of complex interactions between the resin(s) and nanoparticles involved (thermodynamic factors) and the thermo-mechanical history (kinetic factors) that is experienced during processing. This microstructure is strongly influenced by resin and nanoparticle parameters such as surface energy and interfacial tension as well as their rheological and thermodynamic properties. In this study, the results of recent studies on the seal strength of nanocomposites and nanocomposite blends films will be discussed. The effect of clay dispersion and type as well as blend components on peelability of hot seals is studied.