Using nanoparticles is a feasible and efficient way to tailor the phase morphology and resultant properties of polymer blends. In this work, nanoparticles that with strong self-networking capability in polymer melts, such as silica (SiO2) and Carbon Black (CB), were successfully used to tailor the phase morphology and properties of 85PLA/15PU blends. It was found that the addition of SiO2 or CB can both induce the formation of special co-continuous like structure, which leads to a dramatic improvement in impact toughness with strength and modulus well maintained and even electricity conductivity when CB was used. This inspiring result proves the introduction of nanoparticles with self-networking capability into polymers blends to be a universal platform to design their performance via tuning the phase structure.