Hybrid Particles with unique chemical components and surface morphologies possess fascinating properties which have drawn wide spread attention in both academic and industrial settings. In that regard, the unique hybrid building block, simple and convenient synthetic methods are highly demand for the preparation and application of hybrid particle. Polyhedral oligomeric silsesquioxane (POSS) is cage-like, nano-sized molecules composed of an inorganic scaffold (Si8O12) and organic coronae (R), which is a typical hybrid nanoparticle and has extensively explored in the preparation of composites. Herein, we utilized POSS as a nano-building block for fabrication POSS-containing microparticles with various POSS content. The dispersion polymerization method based on thiol-Michael addition reactions or thiol-epoxy reactions were applied for the preparation of cross-linked, narrow dispersity POSS-containing microparticles (PCMs). The formed PCMs have tunable Tgs and extremely high thermal stabilities, and the organic chains of PCMs could be removed by high temperature. The sphere morphology was not collapse after the high temperature treatment, but with the diameter shrinking from 1-2 ìm to 500-800 nm and obtained novel silica nanoparticles. Besides, these PCMs were easily functionalized with various thiol related functional groups, which endowed PCMs with desirable properties. Moreover, both smooth sphere and raspberry PCMs were scalable obtained by using one-pot thiol-Michael or thiol-epoxy dispersion polymerization with tunable surface roughness. The properties of PCMs were investigated, some preliminary results suggested that these PCMs can be used as sensors, coatings, and rheology modifiers. These results provide some new information for researchers to fabricate organic and inorganic hybrid microparticles with tunable and desired functionality.