Since extrusion is one of the most important manufacturing processes due to the increasing demand of polymer products, the melt quality of the polymer plays a crucial role. Indeed, the melt quality dependents on the condition of preparing and processing the polymer. In this matter, the resulting melt quality is highly reliant on the parameter settings of the extruder machine. Polymer materials have a temperature-dependent behavior hence, the temperature progress over time is a significant aspect. In the wake of this, the determination of a decent barrel temperature is of high interest. A thermal homogeneous polymer melt as well as an increase of the throughput is conceivable. In contrast to this, an improper barrel temperature setting can lead to a deterioration of the material. Nowadays, the temperature of the barrel is either set with the help of an experienced process engineer or the by seeking for advice from the resin manufacturer. If neither option is possible, the barrel temperature can be set by applying trial and error experiments. Rather than assuming the “correct” barrel temperature setting, it is more efficient to identify the correct barrel temperature setting by means of measured quality criterions. In this paper target criterion are focused in order to reflect the quality of the extruded polymer. Different temperature settings are examined to find correlations between the barrel temperature setting and the corresponding target criterions. Certainly, an extruder that self-corrects the barrel temperature in order to meet an optimal barrel temperature setting regardless of the screw geometry and the resin is highly preferable. This is why rules of conduct are derived from the process behavior of the extruder. In this manner those rules can be used as a basement for a temperature setting control algorithm for a self-optimizing temperature setting control to meet a better melt quality.