Reactive compatibilization of two immiscible polymers was demonstrated to be an efficient way to produce high performance materials. Recently, we designed and synthesized a series of reactive comb-like polymers by copolymerizing methyl methacrylate (or styrene), glycidyl methacrylate and poly(methyl methacrylate) macromonomer. The obtained comb-like polymer was found to be an efficient compatibilizer for several polymer blends. For example, PLLA/PVDF blends formed unevenly dispersed droplets of PVDF, while the addition of 3 wt% of comb-like polymers mentioned above significantly reduced the domain sizes of PVDF, which implied the improved compatibility of PLLA/PVDF blend. The tensile tests showed that the modulus and the ductility of the blends compatibilized by comb-like polymers were significantly improved compared to the blends compatibilized by their linear counterparts. We further expanded the basic reactive compatibilization principle to the micellar compabilization and the reactive nanoparticle compatibilization. The investigation paves new routes for the reactive compatibilizatoin.