For numerical analysis methods, such as finite element method or finite volume method, the domain needs to be discretized by meshing it. In general, In order to analyze the continuous field in the domain, the elements of different components need to be connected by shared nodes and surfaces. However when creating the mesh, the perfect connection between elements has challenges, especially for complex structure of model. For injection molding simulation, In addition to plastic parts, there are also components of the mold. Different components require different types of mesh, but at the interface between components need to share nodes, which increases the difficulty of creating mesh. In this study, the non-matching mesh was applied into the injection molding simulation. When users generate a mesh, do not need to consider the continuity of the mesh between components. This can reduce the difficulty of mesh generation and save user processing time. Whether cool analysis or warp analysis, the use of non-matching mesh can get similar results with the matching mesh. Keywords: Non-Matching Mesh, Moldex3D, Injection Molding