We developed a biodegradable three-dimensional-printed polylactide (PLA) cage for promoting bony fixation and an antibiotics-embedded poly(D,L)-lactide-co-glycolide (PLGA) nanofibrous membrane for infectious prophylaxis during treating the comminuted metaphyseal fracture in a rabbit femoral model. The in vitro studies included measuring the mechanical properties of the 3D printed cage and determining release activities of vancomycin and ceftazidime from the nanofibers. The results showed that vancomycin and ceftazidime were sustainably detected above the effective levels in the local tissue fluid around the fracture site for 3 weeks.