In this study, three series of dendritic monomers (B, T, O) were prepared from cystamine dihydrochloride (Cy) as the internal core, and the compounds were reacted with acryloyl chloride (AC) to obtain the Cy octa-acrylamide (O-AAm) and Cy tetra-acrylamide (T-AAm) and BACy (bis-acrylamide) which contain vinyl group in the end-cap. Three series of thermosensitive hydrogels (Tx, Ox, and Bx) were then prepared from N-isopropyl acrylamide (NIPAAm) as monomer, O-AAm, T-AAm and BACy as crosslinkers. In this study, the effect of the crosslinker content in the hydrogel on the various properties such as swelling behavior and mechanical properties of a series of hydrogels under before and after decomposition of the disulfide bonds in the hydrogel with cystamine into mercaptans, then further oxidize with hydrogen peroxide to become the sulfonic acid groups was measured. The results showed that the equilibrium swelling degree of the hydrogel before decomposition was in the order of T1.5> O0.75> T3> O1.5> B3> B6. The addition of hydrophilic crosslinker into the hydrogels makes the CGTT of Tx and Ox hydrogels increase. Moreover, the prepared hydrogels still have thermoreversibility and re-usability. The CGTTs of the Bx, Tx, and Ox hydrogels are 32 ℃, 38℃ and 38℃, respectively. In mechanical properties, the reduction of the disulfide bond increases the internal space of the hydrogel, and the sulfonic acid group with good hydrophilicity makes the hydrogel swell more and becomes soft, so the shear modulus and Young's modulus (ρx) of the hydrogels are lower than those of the hydrogels before decomposition. Keywords：Dendritic, Cystamine, Degradable, Thermosensitive, hydrogels