Three-dimensional simulation for polyurethane (PU) foam produced in a mold is developed in this study. Reaction kinetics model, density model, and viscosity model are applied to describe the complex polyurethane foam system in the simulation study. The effect of mold rotation during the foaming process is also considered. The fluid front time, the density of PU foam, foaming behavior, and curing conversion are examined to understand the dynamic behavior of the polyurethane material in both filling and foaming stages. It will be helpful to understand the mold filling behavior in the PU foam molding process. Keywords: Polyurethane Foam Molding, Numerical simulation, Curing kinetics and foaming kinetics, Mold rotation