In order to reduce the gas permeation through polymer films layered particles are a suitable method by elongating the path of diffusion according to the Nielson model. High aspect ratio and orientation of fillers are the key parameters for this effect. Graphene offers in this respect extraordinary good possibilities, if exfoliated and well dispersed. Therefore, different commercially available types of graphene were compounded with semi-aromatic and aliphatic polyamide grades in laboratory scale and extruded to flat film. Composition and process parameters of compounding as well as of flat film extrusion were varied. Extruded samples were investigated using microscopy, rheology and permeation rate of Helium (He) as a very small probe molecule. The results show that there is no obvious correlation between permeation rate and filling level and processing conditions, whereas rheological experiments emphasize better interaction in case of semi-aromatic than aliphatic polyamide. It will be shown that besides the usual critical parameters like dispersion, distribution and platelet orientation the degassing of the matrix is one of the critical points. This phenomenon will be discussed and ways to avoid a non acceptable gas bubble concentration will be shown.