Acetone is an organic solvent; it is volatile and flammable and is a widely used solvent in the industry. According to the Occupational Safety and Health Administration (OSHA) the permissible exposure limit of acetone in air is 1000 ppm; above this value it can be harmful for humans. Many techniques have been used to measure acetone in air, like: Gas chromatography, Flame Ionization Detection, Ion Mobility Spectrometry and Mass Spectrometry to mention some2. These techniques have a number of limitations to be used in real time monitoring, because they require sample preparation, qualified personal and they are relatively expensive. Other option to very precisely measure the concentration of acetone in air is the Surface-Enhanced Raman Spectroscopy, a versatile molecular spectroscopic technique, which is sensitive, rapid, and accurate. In this present work we use Silver nanoparticles (AgNPs) on the surface of Polystyrene subtract (PS) for improving the Raman signal at low analite concentrations, silver nanoparticles act as Raman enhancers helping to detect an analite. This work presents the results of synthetizing Polystyrene/Silver nanoparticles (Ps/AgNPs) to be used as the sensitive section in a detector of acetone by Raman Spectroscopy.