pps proceeding - Abstract Preview
pps proceeding
Symposium: S20 - Soft matter applications
Oral Presentation
 
 

PVA-Borax-Curcumin Hydrogel: Correlation between viscoelastic properties and drug release rate

Rezvan Gelareh (1), Pircheraghi Gholamreza (1)*, Bagheri Reza (1)

(1) Sharif University of Technology - Tehran - Iran

In the present work, polyvinyl alcohol (PVA) hydrogel physically crosslinked using disodium tetraborate (Borax) have been prepared at different PVA: Borax ratios. To study the drug release rate as a function of viscoelastic properties of prepared hydrogels, fixed amount of curcumin encapsulated in pluronic F127 micelle were loaded to hydrogels and drug release rates were investigated in PBS solution using UV-Vis spectroscopy at two temperatures, i.e. 25 and 37°C. Interactions between PVA chains and Borax and curcumin molecules were studied by means of FTIR spectroscopy, while viscoelastic properties of prepared hydrogels were measured in the oscillatory shear mode at linear viscoelastic region. It was observed that with increasing the Borax: PVA ratio the low frequencies storage modulus shows an increasing-decreasing trend. The highest storage modulus and complex viscosity were achieved in a hydrogel sample prepared by PVA: borax ratio of 4: 1. While, Curcumin release rate shows a non-fickian power law behavior at studied temperatures. Interestingly it was observed that there is a linear relationship between the power law exponent of drug release rate, n, and viscoelastic parameter of hydrogels, R, which is defined as crossover frequency divided by plateau storage modulus. These results showed it could be possible to predict drug release rate from viscoelastic properties of curcumin loaded PB hydrogel.