At present, polymer extrusion is one of the most important manufacturing processes due to the increasing demand of polymer products. In order to promote the desired amounts of any polymer product, the melt quality of the polymer plays a crucial role. The melt quality is not solely dependent on the chemical composition of the base polymer but also on the conditions of preparing and processing the polymer. Indeed, the resulting melt quality is highly dependent on the parameter settings of the extruder. Since polymer materials have a temperature-dependent behavior, the temperature progress over time is one significant aspect. Hence, the thermal loading of the polymer particles during the extrusion process is essential to preserve a good melt quality. In the wake of this, the determination of the optimal barrel temperature profile along the extruder is one of the primary responsibilities in the extrusion area. Besides, generating a thermal homogeneous polymer melt, an increase of the throughput, consequently an increase of the economic efficiency, is possible. In return, an unflattering barrel temperature can lead to a deterioration of the material properties and in this manner, it will lead to a decrease in the economic efficiency. In addition to that, the melting profile, and therefore the pressure behavior during the process, is influenced by the barrel temperature. Therefore, an inconvenient barrel temperature setting can lead to an enhanced wear of the screw and the barrel. This article examines the effect of different barrel temperature profiles on the process behavior. Firstly, different criteria are considered for defining or respectively measuring the melt quality. After that, two different strategies to determine a convenient barrel temperature setting are taken into account. The collected data is utilized to generate correlations between the barrel temperature setting of each barrel zone and the polymer melt quality.