By means of using diverse materials, various properties were able to be integrated in according areas of multicomponent parts. These processes are well-established for the production of thermoplastic components. When it comes to technical applications that have higher requirements for the employed materials, thermoplastic elastomers (TPEs) reach their limits. Silicones are much better suited for such requirements. Due to the varying morphological material characteristics, the creation of a strong bond between the different components is still challenging. Different theories exist that attempt to explain how these combinations could work. To investigate on how the injection molding process and its parameter settings influence the bond between the different components a modular tool was designed for the production of multicomponent specimens. In this tool, a thermoplastic plate is molded on the one side, and is then automatically transferred by a robot system to be overmolded with silicone on the other side. The approach presented in the VDI 2019 guideline “Testing the Adhesion of Thermoplastic Elastomers (TPE) on Injection-Molded Substrates” was chosen for testing the material composites, which consisted of thermoplastics and LSR. Using an all-electric Arburg Allrounder 370A multicomponent injection molding machine composite samples were produced. In this study the thermoplastic plates were made of polyamide 6 (Ultramid B3K by BASF) and a self bonding liquid silicone rubber (Elastosil LR 3070 by Wacker) was used for overmolding. The parameters for the thermoplastic injection molding process as well as for the liquid injection molding process (LIM) were varied. It was found out that only by varying the process parameters the resulting bonding strength can be influenced by up to 30%.