Polymer blending is one of the most straightforwardly implementable strategies to enhance the properties of Polylactide (PLA) such as mechanical performances aiming at extending its applications. PLA is generally blended with acrylonitrile-butadiene-styrene (ABS), a polymer with interesting thermal and mechanical properties. However, the incompatibility between PLA and ABS remains a challenge requiring a compatibilization to obtain a good combination of both polymers. Cardanol, a naturally occurring phenolic compound, has been used to compatibilize PLA and ABS by reactive extrusion. In this presentation, we will detail the compatibilization mechanisms based on the reaction of cardanol with the polymers. The impact of this bio-compatibilizer onto the final materials properties will be given to evidence its efficiency