Thermoforming of thermoplastic prepregs is a fast manufacturing process. It is suitable for automotive composite parts manufacturing. In this paper, the simulation of thermoplastic prepreg forming is achieved by alternate thermal and forming analyses. The thermal properties are obtained from a mesoscopic analysis and a homogenization procedure. The forming simulation is based on a viscous-hyperelastic approach. The thermal simulations define the coefficients of the mechanical model that depend on the temperature. The forming simulations modify the boundary conditions and the internal geometry of the thermal analyses. The comparison of the simulation with an experimental thermoforming of a part representative of automotive applications shows the efficiency of the approach.