Dendrimers are monodisperse nanosized polymeric molecules composed of a large number of perfectly branched monomers. The versatile chemical composition of dendrimers offers a variety of applications in different area such as: chemistry, biology, and medicine. The potential of using dendrimers as carries for drug delivery is revolutionizing medicine by improving the efficiency and reducing the toxicity of various treatments(1). Dendrimers can form either covalent or noncovalent (encapsulation) bounds with bioactive molecules. In the case of covalent bound, drug can be attached to dendrimer directly or via a linker and the resulting drug-loaded dendrimer can act as a nanovehicle for drug transport and controlled release. In this communication we will present the synthesis and characterization of new phosphorus dendrimers(2) (generations Gc1 to Gc3) containing various functional groups on their peripheries(3). We will report also the synthesis of different biologically active small molecules and their attachment to phosphorus dendrimer surface using different linkers. All the new drug-dendrimer conjugates are evaluated for their biological activities and these results will be described in this communication. (1)a) R. K. Tekade, P. V. Kumar, N. K. Jain, Chem. Rev. 109, 2009, 49. b) S. H. Medina, M. E. H. El-Sayed, Chem. Rev. 109, 2009, 3141.(2)a) A. Perez-Anes, G. Spataro, Y. Coppel, C. Moog, M. Blanzat, C-O. Turrin, A-M. Caminade, Rico- I. Lattes, Majoral, J-P. Org. Biomol. Chem. 7, 2009, 3491. b) S. Fruchon, M. Poupot, L. Martinet, C-O Turrin, J-P. Majoral, J-J. Fournié, A-M. Caminade, R. Poupot. J. Leuko. Biol. 85, 2009, 553.(3)a) N. El Brahmi, S. El Kazzouli, S. Mignani, E. M. Essassi, G. Aubert, R. Laurent, A. M. Caminade, M. Bousmina, T. Cresteil, J-P. Majoral. Mol. Pharmaceutics. 10, 2013, 1459-1464. b) N. El Brahmi, S. Mignani, J. Caron, S. El Kazzouli, M. Bousmina, A. M. Caminade, T. Cresteil, J. P. Majoral. Nanoscale. 7(9), 2015, 3915-3922.