Poly (vinyl chloride) (PVC) is one of the most employed polymers in the world and it is interesting to change some of its properties to broaden its usage. In this paper we aim to evaluate the effect of the plasticizer type and the mixture method of clay dispersion in the PVC matrix. It was employed three plasticizers: dyoctil adipate (DOA), dioctyl phthalate (DOP) and a green plasticizer (poly- ε-caprolactone – PCL). Besides, it was also evaluated the effect of clay pre-dispersion in plasticizer using two mixture methods: sonication and mechanical mixture. It was characterized the morphology by transmition electronic microscopy and mechanical properties by stress-strain test. It was observed a heterogenic dispersion of the clay in PVC matrix and different plasticization regions. However, the pre-dispersion decreased clay agglomerates size and intercalated/expholiated regions were also observed. The clay addition increased 5% and 10% on Young´s modulus for PVC/DOP with clay dispersion using sonication methods and PVC/PCL with clay dispersion using mechanic mixture, respectively. The DOA addition leads to a decrease in Young´s modulus. According to these results, it can be reasoned that clay pre-dispersion in plasticizer may facilitate intercalation but does not eliminate all of clay agglomerates, and the type of plasticizer influences on mechanical properties of plasticized PVC/clay.