Polylactide (PLA) is a biodegradable aliphatic polyester with a good transparency and high tensile strength. However, its brittleness and cost become major drawbacks. Balancing between the mechanical properties and cost is a key to making PLA more competitive to existing commercial plastics. The aim of this research was to study the effect of plasticizer content and filler on the mechanical properties of poly(lactic acid). The different poly(lactic acid) grades, PLA 4043D, PLA 2003D and PLA 3052D, were selected and melt-mixed with 2 to 14 wt% of Polysorb®ID46 as a plasticizer via an internal mixer. The melt flow index increased with the amounts of plasticizes added. The tensile results demonstrated that upon increasing concentrations of plasticizers, it resulted in a decreased Young’s modulus and tensile strength whereas elongation at break increased drastically when adding of the plasticizer above 12 wt% (330%) for all PLA grades. PLA 4043D and PLA 2003D were showed slightly decreased Young’s modulus when increasing plasticizer content, whereas elongation at break was still high. Tanδ peaks of plasticized PLA were shifted to the lower temperature with increasing plasticizer concentrations. 3-15 phr of Talc was then added to 12 wt% and 14 wt% of the plasticizer in PLA. Dynamic mechanical properties of Talc filled-plasticized PLA samples were recorded. The results showed that when Talc contents were increased for both plasticized PLA ratios, the storage modulus and the complex viscosity tended to increase. The effect on mechanical properties was less pronounced for 12 wt% plasticized PLA compared to 14 wt% plasticized PLA because it showed the slow decreasing rate of Young’s modulus and tensile strength whereas the elongation at break was still very high compared with neat PLA. For PLA 4043D, the addition of even higher amounts of Talc could increase Young’s modulus and tensile strength while maintaining the elongation property.