Kedafi Belkhir*, Corinne Jegat, Mohamed Taha Ingénierie des Matériaux Polymères (IMP), UMR CNRS 5223, Université de Saint-Etienne, Jean Monnet, F-42023, Saint-Etienne, France Université de Lyon, F-42023, Saint-Etienne, France e-mail address kedafi.belkhir@univ-st-etienne.fr Macromolecular architectures are of great importance in contemporary polymer science, the control over polymer design, functionality, composition and topology allows the elaboration of polymers with various properties, different behaviors and a large field of applications. [1,2] In a recent work, [3] we have reported a facile new method to synthesize branched polymers with controlled macromolecular architectures; these materials have been endowed with high controlled thiol functionalities and based on biodegradable polymeric segments, their structures and functionalities were confirmed by spectroscopic analyses and a new chemical method was adapted. The effect of the macromolecular design on thermal properties of these materials was investigated. These materials with thiol functions offer opportunity to further modifications: a thiol-ene click chemistry approach has allowed to graft molecules with active sites on these functional materials thus giving them a biological activity. The kinetic of grafting was studied and the amount of active sites in the materials was controllable. The processability of the final products was investigated in melt state; they were also blended with matricial polymers, such as polylactic acid and polycaprolactone for applications in packaging and coatings. Morphologies like droplets in matrix to co-continuous were obtained. Physico-chemical and rheological properties were investigated. Biodegradability and antibacterial activity were also controlled. References 1) Bernhard V.K.J.Schmidt, Martin Hetzer, Helmut Ritter, Christopher Barner-Kowollik, Progress in Polymer Science, 2014, 39, 235. 2) Andrew Gregory, Martina H. Stenzel, Progress in Polymer Science, 2012, 37, 38. 3) Kedafi Belkhir, Hang Shen, Jianding Chen, Corinne Jegat, Mohamed Taha, European Polymer Journal, 2015, 66, 290.