Polymers that change their properties in response to different stimuli (e.g. light, temperature, pH, ionic strength or magnetic field) are attracting great interest and have been widely used in biomedical applications such as sensors, gene delivery, drug delivery or tissue engineering. Temperature-responsive polymers have been studied extensively for controlled drug delivery applications. Poly (2-alky-2-oxazoline)s, exhibiting lower critical solution temperature behavior, are of growing interest due to their nontoxic behavior and chemical structure resembling to peptides. Layer-by-layer technique (LBL) is a powerful technique to prepare ultra-thin films with an advantage of nanometer scale control in film thickness. Moreover, multilayers can be constructed on any type of surface through non-covalent interactions including electrostatic, hydrogen bonding, charge-transfer or hydrophobic-hydrophobic interactions among the polymer pairs. In the present study, hydrogen-bonded multilayer films of poly (2-alky-2-oxazoline) s with Tannic Acid were prepared as platforms to release Doxorubicin (DOX) from surface via pH and temperature triggers. Poly (2-isopropyl-2-oxazoline) (PIPOX) and poly (2-ethyl-2-oxazoline) (PETOX) were synthesized via cationic ring opening polymerization (CROP) with hydroxyl end groups. Prior to film construction, water soluble complexes of Tannic Acid and Doxorubicin were prepared. Such TA-DOX complexes and PETOX or PIPOX were then layer-by-layer deposited at the surface. Release of DOX from the surface was induced via pH trigger. Effects of temperature on the release of DOX at acidic conditions were examined in detail.