The development of types of LSR with modified adhesive properties enabled the injection molding of thermoplasts to be performed without surface activation. This made it possible for complex components that consist of hard-soft components to be manufactured with low production costs. The adhesion mechanisms induced in the marginal layer during overmolding are meant to lead to a firmly bonded connection of the components so as to obtain a durable composite. However, there are numerous influencing factors and reciprocal effects that affect the quality of the composite strength. These are the material compatibility, the construction of the molded component, the types of stress, and the manufacturing conditions. The injection molding process parameters represent a significant challenge in practice for processing parties in regards to guaranteeing a consistent level of adhesion of the self-adhesive LSR on the thermoplast. An analysis that employed statistic experiment planning was performed to determine the process parameters that are of significance for composite adhesion. It became clear that the temperatures of the tool wall, the holding pressure, and the vulcanization time decisively influence the adhesive strength of the material combination PA6 and self-adhesive LSR. These substantial factors were examined in depth in the further course of events, and a regression equation was created that enables the theoretical composite adhesion to be calculated. The VDI guideline 2019, which defines a standard sample geometry and the execution of peel tests, was used to determine the adhesive strengths.