In this work, the poly(methyl methacrylate-co-methacrylic acid)/poly(methacrylic acid-co-N-isopropylacrylamide) thermosensitive composite semi-hollow latex particles were synthesized by three processes. The first process was to synthesize the poly(methyl methacrylate-co-methacrylic acid) (poly(MMA-MAA)) copolymer latex particles by the method of soapless emulsion polymerization. The second process was to polymerize methacrylic acid (MAA), N-isopropylacrylamide (NIPAAm) and crosslinking agent, N,N’-Methylenebisacrylamide (MBA), in the presence of poly(MMA-MAA) latex particles to form the linear poly(MMA-MAA)/crosslinking poly(MAA-NIPAAm) core-shell latex particles with solid structure. In the third process, part of the linear poly(MMA-MAA) core of core-shell latex particles was dissolved by ammonia to form the thermosensitive poly(MMA-MAA)/poly(MAA-NIPAAm) semi-hollow latex particles. The morphologies of the semi-hollow latex particles show that there is a hollow zone between the linear poly(MMA-MAA) core and the crosslinked poly(MAA-NIPAAm) shell. The crosslinking agent and shell composition significantly influenced the lower critical solution temperature (LCST) of poly(MMA-MAA)/poly(MAA-NIPAAm) semi-hollow latex particles. Besides, the gold nanoparticles (Au NP) were produced by the method of condensation, and wrapped in the thermosensitive poly(MMA-MAA)/poly(MAA-NIPAAm) semi-hollow latex particles to form the poly(MMA-MAA)/poly(MAA-NIPAAm)/Au semi-hollow composite latex particles, and then the composite latex particles were used as carriers to load with Arbutin. The morphologies and the behavior of control release of the composite latex particles were investigated.