Conducting polymer based hydrogels exhibit physical properties analogous to those of human tissues. They are soft materials with high water content that can be made stimuli-responsive through altering their properties. Combining the unique features of hydrogels with the high electrical conductivity of conducting polymers, a mesh-like three dimensional network can be obtained in which the conjugated polymer acts as the single continuous conductive phase. These electrically conductive hydrogels respond to the outside pressure perturbations through a piezoresistive response which makes them promising candidates for resistive-type sensors with ultra-high sensitivity mimicking some major properties of human skin. In order to imitate natural skin, an electronic skin (E-skin) should be able to recognize both medium and low pressure perturbations. The former ranges from 10 to 100 kPa suitable for object manipulation while the latter is lower than 10 kPa for gentle touch. Herein, using a multiphase reaction, a polypyrrole (PPy) based hydrogel is fabricated as a pressure sensor for E-skin applications. Embedding different additives (i.e., carbon nanotubes and graphene nano platelets) and formulating different microstructures, a highly sensitive pressure sensor with tailored elastic properties is produced. The fabricated PPy based hydrogel can elastically deform and recover upon applying a mechanically induced compression load within the range of human skin detection. The intrinsic elasticity of these hydrogels originates from the hollow micro-spherical structure of the polymerized PPy forming a cross-linked network within the gel. Moreover, incorporation of PPy nanowires as the host matrix of these gels and its effect on the piezoresistive response of the sensor have been investigated. It is shown that due to the high surface area of the polymerized nanowires, the sensor exhibits a high sensitivity to the applied pressure while maintaining a good mechanical performance.