Nowadays, the use of renewable biobased carbon feedstock is highly taken into consideration because it offers the intrinsic value of a reduced carbon footprint and an improved life cycle analysis (LCA), in agreement with a sustainable development. Polyurethanes are more and more often biobased, since polyols and polyisocyanates can be biobased. Various researches were particularly focused on biobased polyols (i) from fermentation of biomass (white biotechnologies) or (ii) directly extracted from biomass and then chemically modified, such as the oleochemical resources. Most of the biobased PU are thermosets, however biobased TPUs (thermoplastics) have been also developed. In this presentation, we report an overview of 10 years of research @University of Strasbourg (France), on the elaboration and characterization of several innovative and biobased polyurethanes systems (PUs, TPUs and NIPUs), with controlled and organized macromolecular architectures. They are synthesized from different biobased building blocks: (i) aliphatic structures from modified glycerides, dimer fatty acids, sugar-based molecules (isosorbide, ) … (ii) and aromatic structures from lignins, tannins and furans. A large range of multiphase systems with nice properties and durable applications can be developed from these different macromolecular architectures, for a greener and durable future.