A novel biological friendly shape memory polymer and self-healing polymer based on poly(propylene carbonate) (PPC)/microfibrillated cellulose (MFC) was prepared. MFC was firstly modified by a one-step mechanic-chemical approach involves ball milling and esterification reaction. In this way MFC could be incorporated into PPC up to 20 wt% with excellent dispersion. The MFC fibers could function as physical cross-linkers to control the mobility of the PPC chains via non-covalent bond interactions, resulting in a significantly enhanced mechanical strength, thermal stability and shape memory property at certain content region (5~10 wt%). In addition, the composites with a MFC content of 5~10 wt% showed a good shape memory effect upon exposure to water at 30 oC due to the hydrophilicity of MFC. More importantly, with the assistance of shape memory effect and the reinforcement of MFC fibers, the polymer composites also showed much enhanced scratch resistance and scratch self-healing behavior. Our work provides a composite approach to tune the shape memory behavior of polymer composites and may contribute to the application of PPC in smart materials field. Keywords: poly(propylene carbonate); microfibrillated cellulose; shape memory; self-healing