Incorporation of different fillers in a polymer matrix can improve various physical and mechanical properties of polymers. Layered silicates, used as nanofillers, are one of the most emphasized research topics in polymer engineering and science in the last decades. The influence of different layered silicates on the tribological properties of Polyamide 46 (PA 46) and Polyamide 66 (PA 66) has been investigated. The nanocomposites with 5 wt.% organoclay were prepared by melt compounding on a co-rotating twin screw extruder. The tribological measurements were carried out on a pin-on-disc type tribometer by pressing a flat pin of steel at a predefined load against a polymer disc sample rotating at a predefined velocity. The disc samples were prepared by injection molding. The coefficient of friction (COF) was measured under oil lubricated conditions at two different temperaturs. To shed light on the particle distribution (agglomerated, intercalated or exfoliated) of the filler occurring in the nanocomposites SAXS measurements and TEM pictures have been taken. For a better understanding of the influence of the nano-scale filler on the formation of the skin layer resulting form the injection molding process additional investigations have been carried out. The results showed that some layered silicates can lead to tremendous reduction in the coefficient of friction (up to 80 %) under oil-lubricated conditions depending on the type layered silicate and the polyamide type used.