The effect of nanoclay incorporation on mechanical and thermo-mechanical properties of polyamide 6 (PA6)/acrylonitrile-butadiene-styrene (ABS) blends compatibilized with two functionalized copolymers were studied. Nanocomposites based on PA6/ABS compatibilized with styrene acrylonitrile-co-maleic anhydride (SANMA) and methyl metacrylate-co-maleic anhydride were prepared with organically modified nanoclay, Cloisite 30B®, by melt compounding in a twin-screw extruder in just one-step. The influence of the different functionalized copolymers and the incorporation of nanoclay were evaluated by X-Ray Diffraction (XRD), Heat Distortion Temperature (HDT), Tensile and Notched Izod Impact Resistance tests. The tensile tests results show that the two reactive copolymers act as an effective compatibilizing agent, improving the toughness of PA6/ABS blends. However, apparently there is no significant difference between SANMA and MMA-MA effects in this system, since the properties of both ternary blends are virtually identical. The XRD results reveal a complete exfoliation of the clay in the nanocomposites. This is expected since Cloisite 30B® is organically modified to interact with polar matrix such as PA6. The addition of clay in the blends dramatically enhance the young’s modulus, however it is followed by a toughness reduction evidenced by a decrease in the impact resistance and elongation at break. A significant increment in HDT was observed due the incorporation of nanoclay in the PA6/ABS compatibilized blends. The increase in young’s modulus and HDT was attributed to the greater extents of silicate platelet exfoliation in the PA6 matrix. Unlike in the ternary blends, the reactive copolymers seems to act in different manners in nanocomposites, whereas the composition compatibilized with SANMA shows slightly better mechanical properties than the one containing MMA-MA.