Shuaishuai Yuan1,2 Huawei Yang1,2 Jinghua Yin 1,* Shifang Luan1 1. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China; 2. University of Chinese Academy of Sciences, Beijing 100049, PR China Corresponding authors. Tel.: +86 431 85262109, Email address: yinjh@ciac.ac.cn Summary For enhancing grafting degree, N-vinyl pyrrolidone (NVP) was used to assist melt grafting of acrylate monomers, i.e., fluorine-containing PEG acrylate monomers (fPEG) and glycidyl methacrylate (GMA) onto styrenic thermoplastic elastomer backbones. With the help of NVP, their grafting efficiencies were increased at least 4 folds. The fPEG graft chains spontaneously enriched on the surface of graft polymer film, the enrichment ratio up to 11 folds were achieved regardless of the casting solvent. The GMA graft chains served as reactive precursor to immobilize hemocompatible poly(ethylene glycol) monomethyl ether (mPEG) via the ring-opening reaction. The as-prepared graft polymers strongly resisted platelet adhesion and protein adsorption relative to the virgin TPS. Keywords: Styrenic thermoplastic elastomer (TPS), Melt grafting, Platelet adhesion, Protein adsorption