Immiscible blends of poly (2,6-dimethyl-1,4-phenylene ether) (PPE) and poly (styrene-co-acrylonitrile) (SAN) were compatibilized using a novel compatibilizer system known as Janus particles. In addition, a reference system compatibilized by a Polystyrene-polybutadiene-poly (methyl methacrylate) triblock copolymer (SBM) was chosen to evaluate the efficiency of the new compatibilization system. Janus particles are three dimensional, two-sided particles with each side having a different chemical structure. In the present work, the Janus micelles had PS and PMMA chains as two different coronas around a cross-linked polybutadiene core. The goal of this investigation is to understand the effect of Janus particles localization at the interface, on the mechanical properties (specifically toughness) of the polymer blends. The blends were compatibilized with 5 and 10 wt.% of Janus particles and SBM using extrusion process. In addition, a blend with 5 wt.% Janus particles and 5 wt.% SBM (10 wt.% compatibilizer in total) has been compounded to investigate the possible synergistic effects of combining compatibilizers. In the ideal case, SBM and Janus particles are expected to be located at the interface as PS is miscible with PPE while PMMA is miscible with SAN. The elastomeric middle block as an immiscible component remains at the interface. This particular morphological arrangement is known as the ‘raspberry morphology’. Fracture toughness measurements have been performed to determine the performance of Janus particles in comparison with SBM triblocks. The results were then interpreted by detailed Scanning Electron Microscopy investigations of the fractured surfaces. The results confirm efficiency of using multiple compatibilizer systems to optimize both the morphology and mechanical properties (toughness) of the polymer blends. The KIC value as well as the E modulus of the system compatibilized with Janus particles and SBM triblocks was improved 30% and 42% respectively.