This presentation will provide examples from our laboratory on the development of biobased materials, there processing and corresponding material properties. By using an engineered yeast strain, fatty acids were converted to omega-hydroxyfatty acids (HOFAs). A route to high molecular weight polymers of HOFAs was developed. By a reactive transesterification extrusion process a family of compatibilized blends of poly(HOFAs) and PLA was developed that retain the strength of PLA but gain ductility (elongation at break about 150%). We will also describe the first process where reactive enzyme-catalyzed processing was used to convert a macrolactone monomer to a poly(HOFA) and to extrude the high molecular weight product. Our laboratory is also developing a family of cutinases that have activity for the complete breakdown of polyesters including PET from thin films to monomers. This has potential use in mild-low temperature PET chemical recycling. Furthermore, we are using cutinase for post-modification of PET and other polyesters. Finally, work will be discussed on developing routes by combining Fischer esterification with acid hydrolysis to obtain modified cellulose nanocrystals (CNs). Relationship were determined between nanofiber modification chemistry and its ability to improve the storage modulus and HDT of these fully biobased materials.