The world is inevitably moving towards renewable energy resources in order to satisfy the demand from the fast-growing global population and to address the concerns over the depleting petroleum resources. In this regard, bioethanol and biodiesel has gained much attention over the last 10-15 years, especially corn-based ethanol. In a corn-based ethanol plant, dried distillers’ grain with solubles (DDGS) is also produced as the coproduct as much as ethanol. The huge expansion of ethanol industry has created surplus amounts of distillers’ grain for its tradition animal feed uses so that its accumulation has become a concern for sustainability of the bioethanol industry. To address the sustainability of corn-ethanol industry and in attempts to find value-added applications for distillers’ grain, researchers have tried to utilize this low-cost animal feed as a filler in polymeric composites. In the present work, we have explored the polymeric composites of distillers’ grains with polypropylene. The properties were tailored by addition of EPDM rubber and maleated PP compatibilizer. A mixture design of experiment has been used to predict the properties of the studied composite system with different levels of the distillers’ grains, rubber and compatibilizer. Each of these three factors was varied in 3 levels. The composite materials were produced by melt extrusion in a micro-compounder followed by injection molding in a micro-injection machine. The composites were characterized for their tensile, flexural and impact properties. Also, heat deflection temperature and melt flow index were measured. The results showed that with the applied mixture design methodology, composites of distillers’ grain and polyolefin can be produced having balanced mechanical, physical and thermal performance. Such an analysis can be effectively used for utilization of distillers’ grain in real world applications.