pps proceeding - Abstract Preview
pps proceeding
Symposium: S06 - Nanocomposites
Oral Presentation
 
 

Mineralized polymer composites as biogenic bone substitute material

Shah Rushita (1), Saha Nabanita (2)*, Kitano Takeshi (2), Saha Petr (2)

(1) Polymer Centre, Faculty of Technology,Tomas Bata University in Zlin - Zlin - Czech, (2) Centre of Polymer Systems,Tomas Bata University in Zlin - Zlin - Czech

Mineralized polymer composites are recognized as potential fillers of bone defects. Minerals like calcium phosphate, hydroxyapatite and calcium carbonate have demonstrated adequate biocompatibility and suitability for the treatment of osteoinduction, osteoconduction, osseointegration and adynamic bone disorder. Though bioceramics exhibits quite a good bone-bonding and vascularization, it is considered too stiff and brittle to be used alone. The use of polymer scaffold instead of bioceramics has several advantages including combining the osteoconductivity and bone-bonding potential of the inorganic phase with the porosity and interconnectivity of the three-dimensional construct [1]. Aiming the advantages of ceramic-polymer composite scaffolds, the calcium carbonate (CaCO3) based biomineralized scaffold was prepared following the liquid diffusion mineralization [2] using CaCl2 (1.32 M, 14.7 %, pH 8.4) and Na2CO3 (1.0M, 10.5 %, pH 7.4) solutions at stable room temperature. The PVP-CMC hydrogel [3] was used as an extracellular matrix [4] for biomimetic mineralization and their physical properties are characterised. The interesting results about morphology, swelling and viscoelastic properties of PVP-CMC-CaCO3 biogenic composites will be presented. The absorption capacity of biomineral as well as swelling ratio of mineralized polymer composites varies with temperature, pH, incubation period and matrix thickness. The swelling properties of this biomaterial had also been investigated in presence of physiological solution, an isotonic body fluid temperature and pH considering its biogenic application.This calcite based polymer composite can be applicable for the treatment of adyanamic bone disorder. Reference: 1.Davis H.E. and Leach J.K, Multifunctional Biomaterials and Devices, Ed. N Ashammakhi, Chapter 10, 2008, 1-26 2.Rauch, M.W.; Dressler, M.; Scheel, H.; Opdenbosch, D.V and Zollfrank, C. Eur. J.Inorg. Che. 2012, 5192-5198. 3.Saha P, Saha N, Roy N. “Hydrogel Wound Covering” Patent no: 302405, 2011,Czech Republic. 4.Smith, E.A.; Li, H.; Keene, E.C.; Seh, Z.W and Estroff. L.A. Adv. Funct. Mater. 2012, 22, 2891–2914