pps proceeding - Abstract Preview
pps proceeding
Symposium: S13 - Polymer Blends
Poster Presentation
 
 

Use of High Speed Separation for Multi Dimensional Chromatographic Analysis During Polymer Synthesis

Jacobsen Jens A. (1)*, O´Leary Michael (2)

(1) Waters GmbH - Hessen - Germany, (2) Waters Corporation - MA - USA

Recent developments in polymeric material have utilized a wide array of strategies relying on complex chemistries. The development of polymeric materials has evolved from simple homo polymers to complex polymers capable of performing multiple functions within a single molecular chain. As these new materials evolve the control and understanding of these chemicals has come under intense scrutiny utilizing a wide range of analytical technology ranging from chromatographic separation to advanced mass spectrometry. Addressing the challenges of material characterization has often been focused on the so called hyphenated techniques such as two dimensional separation followed by multiple dimensional detection. As these analytical schemes become more complex a need for automation and online approaches are required for ease of use as well as quality of data output. One approach, online two dimensional chromatography, has seen significant advances. Online two dimensional liquid chromatography (LC × LC) offers unique advantages over traditional single dimensional chromatography as it allows for direct investigation of material composition. Polymeric characteristics as well as polymer composition information is obtained allowing for understanding of material composition and distribution. In this study we demonstrate the ability and flexibility of this two dimensional separation technique to rapidly isolate material sets based on high speed size separation and ultra performance gradient affinity separation coupled to material specific detection modes allowing for monitoring material composition and establishing polymeric maps to guide development and process optimization for control and consistent performance.