The mechanical properties of thermoplastic vulcanizates, TPVs, depend strongly on their morphologies, which themselves depend on the properties of the primary polymers, the composition of the TPV and the crosslink system and crosslink process. The morphology is defined during the dynamic vulcanization. This work deals with the study of the influence of crosslink systems on TPVs based on PA(6/66)/NBR (co-polyamide PA6/66 and nitrile rubber) in different compositions (40/60, 35/65, 30/70 in mass). Dicumyl peroxide, bismaleimide, phenolic resin, a sulfur-accelerated system and dicumyl peroxide with two co-agents were used as crosslinkers. TPVs were characterized by taking into account their mechanical behavior, solvent resistance, compression set, morphology and thermal properties. The curing system constituted by dicumyl peroxide and bismaleimide/sulfur (DCP/BMI/sulfur) as co-agents resulted in a TPV with a well defined morphology and consequently in a material with a very good mechanical performance and good oil resistance. The addition of inorganic fillers as carbon black, (N330), or clay (montmorillonite), has not brought benefits to the systems under investigation.