The structure developed during the injection molding process depends on the complex thermomechanical history that the polymer experiences during the process. During the process, the variation of the temperature, pressure and velocity can be high and very fast, giving rise to a complex distribution of structures and properties within the object. For instance, the morphology developed in the semicrystalline polymers is characterized by a distribution of structures, from the oriented ones in the skin to the isotropic ones in the core, which gives rise to a distribution of the mechanical properties. It is possible to control the structure developed within an injection molded object by modulating mold temperature, pressure, and flow rate during the process. In a recent development of the injection molding process, the mold temperature can be locally modulated. A thin heater was developed and located below a selected part of the cavity surface to have a fast variation of the temperature and to apply temperature cycles during the process. Injection molded objects, obtained with different temperature cycles, were analyzed by atomic force microscopy for the simultaneous characterization of the morphology, orientation, and mechanical properties. Wide-angle x-ray scattering, performed by a synchrotron, allowed analyzing the distribution of crystalline phases within the objects. A software for the simulation of injection molding was applied to find a relationship between the morphology and the local evolutions of pressure, temperature and flow fields, accounting for the thermomechanical history experienced by the polymer. Sub-models were developed to predict the crystallization, in the presence of the flow and in quiescent conditions. A criterium based on the achievement of critical mechanical work and molecular stretch was developed and applied to predict accurately the transition from the oriented structures in the skin to the isotropic structures in the core.