Dextrin is a water-soluble form of starch. This makes it candidate matrix material for solid dosage forms. Glycerol-plasticised thermoplastic dextrin-based nanocomposites were prepared using twin-screw extrusion compounding. The nanofillers included layered double hydroxide (LDH), cellulose nanofibers (CNF) and stearic acid. The time-dependent retrogradation of the compounds was monitored with X-ray diffraction (XRD), high-pressure differential scanning calorimetry (HPDSC), thermogravimetric analysis (TGA), dynamic mechanical analysis (DMA) and scanning electron microscopy (SEM). XRD showed that the inclusion of stearic acid in the formulations led to the formation of amylose-lipid complexes and a reduction in crystallinity. In the absence of amylose-lipid complexes, the LDH was almost fully exfoliated in the polymer matrix. The nature of the nanocomposite present in the compounds controlled the dissolution rate of the pellets in water. Unexpectedly, samples containing only LDH as additive dissolved fastest. Key words: Dextrin; Solid dosage form; nanocomposite; LDH; cellulose nanofibres